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Anna L. Gravier, Omar Shamieh, Carlos Eduardo Paiva, Pedro Emilio Perez-Cruz, Mary Ann Muckaden, Minjeong Park, Eduardo Bruera & David Hui
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سال انتشار: p2020
تعداد صفحات: 8
زبان فایل: انگلیسی
فرمت فایل: pdf
حجم فایل: 1MB
رمز فایل: www.ketabdownload.com
قیمت: 100,000ريال

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DOI: 10.1007/s00520-019-05239-5

Abstract --- Background Few studies have examined meaning in life, a novel existential outcome, in patients with advanced cancer across countries. Objectives We examined differences in meaning in life across 5 countries and identified factors associated with meaning in life. Methods This is a pre-planned secondary analysis of a prospective longitudinal multicenter observational study of patients with advanced cancer. Meaning in life was assessed using a validated scale which examined four domains of meaning: values, purpose, goals, and reflection. The total score ranged from 8 to 32, with a higher score indicating greater meaning in life. Results Among 728 patients, the median meaning in life score was 25/32 (interquartile range 23, 28). There was no significant difference in the total meaning in life score among 5 countries (P = 0.11), though there were differences in domain sub-scores. In the univariate analysis, patients with higher intensity of physical symptoms by ESAS score (pain, fatigue, drowsiness, dyspnea, insomnia), depression, anxiety, spiritual pain, and financial distress had significantly lower meaning in life. However, patients with higher levels of education, who were married, and who had higher optimism had significantly higher meaning in life. In the multivariate analysis, higher total meaning in life scores were significantly associated with greater optimism (multivariate estimate = 0.33, p < 0.001), lower depression (− 0.26, < 0.001), spiritual pain (− 0.19, < 0.001), and financial distress (− 0.16, < 0.001). Conclusion Country of origin was not a determinant of meaning in life. However, meaning in life was significantly associated with optimism, depression, spiritual pain, and financial distress, underscoring the multidimensional nature of this construct and potential opportunities for improvement in addressing meaning in life of patients with advanced cancer


دانلود مقاله معنی در زندگی در بیماران مبتلا به سرطان پیشرفته: یک مطالعه چند ملیتی , دانلود مقاله , معنی در زندگی در بیماران مبتلا به سرطان پیشرفته , Meaning in life in patients with advanced cancer: a multinational study
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