کتاب دانلود کتب لاتین علوم پزشکیداروشناسی و آنتی بیوتیک
ناپایداری پروتئین در رابط ها در جریان توسعه محصول دارویی - درک اساسی، ارزیابی و کاهش
ناپایداری پروتئین در رابط ها در جریان توسعه محصول دارویی - درک اساسی، ارزیابی و کاهش

Protein Instability at Interfaces During Drug Product Development - Fundamental Understanding, Evaluation, and Mitigation
سال انتشار: 2021
تعداد صفحات: 340
زبان فایل: English
فرمت فایل: pdf
حجم فایل: 6MB

دانلود رایگان

Publisher : Springer

ISBN-10 : 3030571769

ISBN-13: 978-3030571764

ASIN : B08WJ6MVQ6

Proteins are exposed to various interfacial stresses during drug product development. They are subjected to air-liquid, liquid-solid, and, sometimes, liquid-liquid interfaces throughout the development cycle-from manufacturing of drug substances to storage and drug delivery. Unlike small molecule drugs, proteins are typically unstable at interfaces where, on adsorption, they often denature and form aggregates, resulting in loss of efficacy and potential immunogenicity.  This book covers both the fundamental aspects of proteins at interfaces and the quantification of interfacial behaviors of proteins. Importantly, this book introduces the industrial aspects of protein instabilities at interfaces, including the processes that introduce new interfaces, evaluation of interfacial instabilities, and mitigation strategies. The audience that this book targets encompasses scientists in the pharmaceutical and biotech industry, as well as faculty and students from academia in the surface science, pharmaceutical, and medicinal chemistry areas.