Actinobacteria: Microbiology to Synthetic Biology

This book summarizes the basics of actinobacteria, from microbiology to  synthetic biology. It focuses on diversity, NRPS, sesquiterpenes,  lantipeptide, bioinformatics apparatuses, cloning, CRISPR, reverse  engineering, FDA supported medications, and marine actinobacteria. It  also covers the latest trends in drug discovery from actinobacteria, and  introduces several recently developed bioinformatics and synthetic  biology tools to explore new antibiotics from actinobacteria.

Many  natural products such as polyketides, isoprenoids, phenazines,  peptides, indolocarbarbazoles, sterols, and others have been isolated  and characterized from actinobacteria. Some products are synthesized by  the non-ribosomal peptide synthetases (NRPSs), polyketide synthases  (PKSs), or other functional genes. Although genome sequencing has  uncovered the differing qualities of these chemicals, recognizing new  items and their biosynthetic pathways is still under examination.

Cryptic  metabolic pathways have been explored using molecular techniques or  culture-dependent approaches. In recent years, researchers’ primary  interest is to identify the specific conditions or agents that wake the  cryptic antibiotics. Several bioinformatics and synthetic biology tools  were developed to explore new antibiotics from actinobacteria.

The  book comprises 14 chapters with different aspects of application and  utilization of actinomycetes from the microbiology; systems biology,  pharmacology of natural products, bioinformatics, actinomycete and its  diversity, CRISPR, artificial Intelligence, synthetic biology, metabolic  engineering, expressional studies, and biosynthetic gene clusters.

The  book delivers useful information on actinomyces to researchers, novices  in genome designing, specialists, clinicians, policymakers, and  professionals.