Flow Cytometry in Neoplastic Hematology: Morphologic-Immunophenotypic-Genetic Correlation

This fourth edition presents an updated and expanded text and   illustrations to reflect continued morphologic, immunophenotypic, and   especially molecular advances in the field of neoplastic hematology,   mostly due to the rapidly expanding application of next-generation   sequencing. Those advances not only allow a more reliable diagnosis of   the majority of tumors and identification of early changes such as   monoclonal B-cell lymphocytosis or clonal hematopoiesis of  indeterminate  potential (CHIP), but also in many cases identify  mutations or  phenotypic changes in tumors that can be targeted by  mutation-specific  or antigen-specific drugs.

This edition  incorporates the updated  WHO classification of hematopoietic tumors and  new immunophenotypic and  molecular markers to provide a thorough  pathologic overview of  hematologic neoplasms while focusing on flow  cytometric features.  Special emphasis has been put on hematological  neoplasms with crucial  clinical significance such as acute  promyelocytic leukemia, other acute  leukemias, and difficult areas in  flow cytometry. Flow cytometric  features in AML, MDS, CMML, CLL and  measurable residual disease were  significantly expanded. There are many  new comparative tables,  illustrations, and diagrams of algorithmic  approaches.