This book Practice Pearls in Neurology—Series 1 is a practical guide to the diagnosis and management of both common and less common neurological disorders and diseases for clinicians and trainees. This book consists of 16 chapters, which covers the management of emergency headache, diabetes mellitus and central nervous system, seizures in systemic disorders, medically refractory epilepsy, emergencies in movement disorders, restless leg syndrome, nonmotor symptoms in Parkinson’s disease, influence of gut microbiota on the brain, neurological manifestations of chronic liver disease, tuberculous meningitis, inflammatory demyelinating polyneuropathy, approach to the management of aphasia, multiple sclerosis in India, phantom limb, paradigm for management of noncompressive myelopathy, and sensory modulation in rehabilitation. Each chapter presents a different condition providing a step by step approach from basic knowledge, history and examination, to key aspects of clinical diagnosis, investigations, and medical and surgical treatment. The continuous publication of the book over the years accumulates huge knowledge, which can be utilized by all the practitioners in neurology.